甲状腺疾患と円形脱毛症の間に遺伝的関連がある可能性
甲状腺機能低下症、橋本病、亜急性甲状腺炎に見られる脱毛症の重要な遺伝的予測
Heping Hospital Affiliated to Changzhi Medical College（中国）のYue Zhao氏らは、2標本のメンデルランダム化解析を用いた研究で、AAと甲状腺疾患の潜在的な因果関係を検証した。甲状腺機能低下症、橋本病、甲状腺機能亢進症、亜急性甲状腺炎、バセドウ病が曝露因子として選択され、AAが結果変数とされた。データはゲノムワイド関連解析（GWAS）から取得された。
解析の結果、甲状腺機能低下症（逆分散加重オッズ比1.40）、橋本病（同1.39）、亜急性甲状腺炎（同0.73）について、AAが統計的に有意な遺伝的予測を示すことが示された。多面性のエビデンスは見られなかった。関連の安定性と頑健性は、leave-one-outテストを使用して実証された。
著者らは、「私たちの研究結果は、甲状腺機能低下症、橋本病、亜急性甲状腺炎が、AAとの間に有意な関連性があることを示しており、内分泌の健康状態と皮膚病理の複雑な相互作用に関する新たな視点を示唆している。これらの発見は、甲状腺疾患とAAの発症機序との関係を示す新たなエビデンスを提供するだけでなく、特にAAの潜在的な治療法を探る上で、将来の研究に新たな方向性を示している」と述べている。
Potential Genetic Link ID'd Between Thyroid Disease, Alopecia Areata
Significant genetic predictions of alopecia seen with hypothyroidism, Hashimoto thyroiditis, and subacute thyroiditis
WEDNESDAY, Oct. 30, 2024 (HealthDay News) -- There seems to be a significant association between hypothyroidism, Hashimoto thyroiditis, subacute thyroiditis, and alopecia areata (AA), according to a study published in the October issue of Skin Research & Technology.
Yue Zhao, from Heping Hospital Affiliated to Changzhi Medical College in China, and colleagues examined the potential causal relationship between AA and thyroid disease in a two-sample Mendelian randomization study. Hypothyroidism, Hashimoto thyroiditis, hyperthyroidism, subacute thyroiditis, and Graves disease were selected as exposure factors and AA was the outcome variable; data were obtained from genome-wide association studies.
The researchers identified statistically significant genetic predictions of AA for hypothyroidism, Hashimoto thyroiditis, and subacute thyroiditis (inverse variance weighted odds ratios, 1.40, 1.39, and 0.73, respectively). No evidence was seen for pleiotropy. The stability and robustness of the association was demonstrated using the leave-one-out test.
"Our findings indicate a significant association between hypothyroidism, Hashimoto's thyroiditis, subacute thyroiditis, and AA, suggesting a new perspective on the complex interplay between endocrine health and skin pathology," the authors write. "These discoveries not only provide new evidence for the relationship between thyroid disease and the pathogenesis of AA but also offer new directions for future research, especially in exploring potential treatments for AA."