遺伝子組み換えブタの腎臓を移植された2人目が死亡
人工心臓植込み患者で初めて臓器移植を受けた患者
54歳のLisa Pisano氏は腎不全と心不全を併発していた。彼女は4月12日にブタの腎臓を移植されたが、その8日後に人工心臓の植込みを受けた。5月29日、人工心臓に関連した不十分な血流により腎臓が損傷したため、外科医は腎臓を摘出しなければならなかった。米ニュージャージー州在住の彼女は腎透析を再開したが、その後ホスピスケアに入ったと担当医はニューヨーク・タイムズ紙に語った。彼女は7月7日に亡くなった。
Pisano氏は、人工心臓を持つ人で初めて臓器移植を受けたことで、医学史に名を刻んだ。タイムズ紙によると、腎不全患者は通常、死亡リスクが高いため、人工心臓は不適格となる。
遺伝子組み換えブタの腎臓を最初に移植された患者は、Richard Slayman氏だ。62歳の同氏は3月に米Mass General Brighamで移植手術を受けた。彼は移植後わずか2週間で退院したが、複雑な医療上の問題から、2カ月以内に死亡した。異種移植の分野はまだ実験的である。人間の臓器が適格でないほど病気が重く、治療を受けなければ死亡するリスクのある患者のみが、動物の臓器の提供を許可されている、とタイムズ紙は報じている。
タイムズ紙によれば、2024年に行われた2件の移植は、米食品医薬品局（FDA）から未承認の治療へのアクセスを許可する「compassionate use」を与えられ、実施された。
American Kidney Fundからの情報は以下Webサイトにて
Second Recipient of Genetically Modified Pig Kidney Has Died
WEDNESDAY, July 10, 2024 (HealthDay News) -- The second person to receive a kidney from a genetically modified pig has died, surgeons at NYU Langone Health announced Tuesday.
The 54-year-old patient, Lisa Pisano, had both kidney failure and heart failure. She received the pig kidney April 12, eight days after she had a mechanical heart pump implanted.
On May 29, surgeons had to remove the kidney because it was damaged by inadequate blood flow related to the heart pump. The New Jersey resident resumed kidney dialysis but later entered hospice care, her doctors told the New York Times. She died Sunday.
“Lisa’s contributions to medicine, surgery and xenotransplantation cannot be overstated,” Dr. Robert Montgomery, director of the NYU Langone Transplant Institute in New York City, told the Times. “Her bravery gave hope to thousands of people living with end-stage kidney or heart failure who could soon benefit from an alternative supply of organs.”
Pisano made medical history when she became the first person with a heart pump to also receive an organ transplant. Patients with kidney failure are usually ineligible for a heart pump because of the high risk of death, the Times reported.
The first patient to receive a genetically modified pig kidney was Richard Slayman. The 62-year-old had the procedure in March at Mass General Brigham in Boston. Though he was discharged just two weeks after his transplant, he had complicated medical issues and died within two months.
The field of xenotransplantation remains experimental: Only patients who are so sick that they are not eligible for a human organ, and who are at risk of dying without treatment, have been cleared to receive animal organs, the Times reported.
The two transplants performed this year were approved under the U.S. Food and Drug Administration’s compassionate use program, according to the Times.
More information
The American Kidney Fund has more on kidney transplants.
SOURCE: New York Times
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IMAGE: Photo: Pisano family/NYU Langone
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