生体腎ドナーは全般的な骨折率が低い
一方、椎体骨折率は高い
米メイヨー・クリニックのHilal Maradit Kremers氏らは、生体腎ドナーの骨折の全般的および部位別リスクを、腎臓を提供する資格があったにもかかわらず提供しなかった一般集団から、厳密にマッチさせた対照群と比較した。解析対象は、生体腎ドナー2,132人と、非腎ドナー対照群2,014人であった。
その結果、腎臓提供日または指標日から調査日までの平均期間は、ドナーで24.2年、対照群で27.6年であった。生体腎ドナーの骨折全般の発生率は、対照群より有意に低かった（標準化発生率比0.89）が、生体腎ドナーの椎体骨折の発生率は、対照群より有意に高かった（同1.42）。
著者らは、「本研究は、ドナーにおける骨折全般の発生率は低かったものの、腎重量の減少と長期の副甲状腺機能亢進症が、生体腎ドナーの海綿骨減少と椎体骨折を発生しやすくしている可能性を示唆している」と述べている。
Living Kidney Donors Have Lower Rates of Fractures Overall
However, living kidney donors have higher rates of vertebral fractures
TUESDAY, Jan. 30, 2024 (HealthDay News) -- During a mean follow-up of 25 years, living kidney donors have a lower rate of overall fractures compared with eligible nondonor controls, according to a study published online Jan. 24 in JAMA Network Open.
Hilal Maradit Kremers, M.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues compared the overall and site-specific risk for fractures among living kidney donors with strictly matched controls from the general population who would have been eligible to donate a kidney but did not do so. The analysis included 2,132 living kidney donors and 2,014 nondonor controls.
The researchers reported that the mean time between donation or index date and survey date was 24.2 years for donors and 27.6 years for controls. They found that the overall rate of fractures among living kidney donors was significantly lower than among controls (standardized incidence ratio, 0.89), although there were significantly more vertebral fractures among living kidney donors versus controls (standardized incidence ratio, 1.42).
"This study suggests that, although the overall fracture rate among donors was low, reductions in kidney mass and prolonged hyperparathyroidism may predispose living kidney donors to trabecular bone loss and vertebral fractures," the authors write.