魚鱗癬はうつ病と不安症のリスク上昇に関連
魚鱗癬患者におけるスクリーニング強化の必要性を示唆
米イェール大学医学部のGloria Chen氏らは、魚鱗癬とうつ病の臨床診断との関連を調べた。分析対象は、「All of Us」リサーチプログラムを通じて特定された先天性魚鱗癬患者334人および対照群1,336人であった。
解析の結果、魚鱗癬患者はマッチさせた対照群と比較して、うつ病（41.9％対23.8％）、不安症（15.9％対7.0％）の診断を受ける可能性が高かった。喫煙状況と甲状腺機能低下症を調整すると、魚鱗癬はうつ病（オッズ比2.33）および不安症（同2.48）と有意に関連していた。
著者らは「魚鱗癬患者におけるうつ病と不安症のリスク上昇が明らかになり、この集団に対する標準治療として日常的なQOLとメンタルヘルスの評価の必要性が強調された。魚鱗癬患者のこの重要な側面に対する配慮は、最適な全人的ケアのために不可欠である」と述べている。
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Ichthyosis Tied to Increased Risk for Depression, Anxiety
Authors say results suggest the need for increased screening in patients with ichthyosis
FRIDAY, Dec. 1, 2023 (HealthDay News) -- Ichthyosis is associated with an increased likelihood of depression and anxiety, according to a research letter published online Oct. 18 in the Journal of the American Academy of Dermatology.
Gloria Chen, from the Yale School of Medicine in New Haven, Connecticut, and colleagues investigated the relationship between ichthyosis and clinical diagnoses of depression and anxiety. The analysis included 334 congenital ichthyosis cases and 1,336 matched controls identified through the All of Us Research Program.
The researchers found that individuals with ichthyosis were more likely to have diagnoses of depression (41.9 versus 23.8 percent) and anxiety (15.9 versus 7.0 percent) than matched controls. When adjusting for smoking status and hypothyroidism, ichthyosis was significantly associated with depression (odds ratio, 2.33) and anxiety (odds ratio, 2.48).
"Our findings of increased risk of depression and anxiety in individuals with ichthyosis highlight the need for routine quality of life and mental health assessments in this population as a standard of care," the authors write. "Attention to this important aspect of these disorders is essential for optimal care of the entire patient."
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